Here we show that SIZ1, the fission yeast Great1p homolog, has a similar temperature-sensitive phenotype. We previously showed that the fission yeast ortholog Great1p can function as a negative regulator of mitotic entry and progression in a temperature-sensitive background. The cyclin-dependent kinase Greatwall regulates cell cycle progression in vertebrates and fission yeast. An active conformation of the cell cycle regulator Greatwall is required for normal mitosis and cytokinesis.

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